منابع مشابه
Synthesis, Antimicrobial and Hypoglycemic Activities of Novel N-(1-Adamantyl)carbothioamide Derivatives.
The reaction of 1-adamantyl isothiocyanate 4 with the various cyclic secondary amines yielded the corresponding N-(1-adamantyl)carbothioamides 5a-e, 6, 7, 8a-c and 9. Similarly, the reaction of 4 with piperazine and trans-2,5-dimethylpiperazine in 2:1 molar ratio yielded the corresponding N,N'-bis(1-adamantyl)piperazine-1,4-dicarbothioamides 10a and 10b, respectively. The reaction of N-(1-adama...
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Amyloid-β peptide ending at the 42nd residue (Aβ42) is implicated in the pathogenesis of Alzheimer's disease (AD). Small compounds that exhibit selective lowering effects on Aβ42 production are termed γ-secretase modulators (GSMs) and are deemed as promising therapeutic agents against AD, although the molecular target as well as the mechanism of action remains controversial. Here, we show that ...
متن کاملSynthesis of 3-bromo-4-isobutyloxyphenyl carbothioamide
3-bromo-4-isobutyloxyphenyl carbothioamide 1 is an important intermediate in many biologically active compounds such as febuxostat. In this work, a rapid synthetic method for compound 1 was established. The compound 1 was synthesized from the commercially available 4-hydroxybenzonitrile 2 through three steps including bromination, oxyalkylation and thioamidation. The structure was confirmed by ...
متن کاملSyntheses and Evaluation of the Analgesic Activity of Some 4-Acetyl- 4-phenylpiperidine and 4-Hydroxy-4-phenylpiperidine Derivatives
Z a fa r S aeed Saify3, K halid M oham m ed K hanb, Syed M oazzam H a id e r3, Z e e sh a n b, Syed T asad aq u e A li S hahb, M uham m ad S aeedc, M oham m ed Saleh S h ek h an id, and W olfgang V o e lte rc a Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi b International Center for Chemical Sciences, HEJ Research Institute of Chemistry, University of Karach...
متن کاملOn the nature of solutions of the difference equation $mathbf{x_{n+1}=x_{n}x_{n-3}-1}$
We investigate the long-term behavior of solutions of the difference equation[ x_{n+1}=x_{n}x_{n-3}-1 ,, n=0 ,, 1 ,, ldots ,, ]noindent where the initial conditions $x_{-3} ,, x_{-2} ,, x_{-1} ,, x_{0}$ are real numbers. In particular, we look at the periodicity and asymptotic periodicity of solutions, as well as the existence of unbounded solutions.
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ژورنال
عنوان ژورنال: Acta Crystallographica Section E Structure Reports Online
سال: 2008
ISSN: 1600-5368
DOI: 10.1107/s1600536808025142